Treatment monitoring and response prediction with proton MR spectroscopy in AD.
نویسندگان
چکیده
In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.
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ورودعنوان ژورنال:
- Neurology
دوره 67 3 شماره
صفحات -
تاریخ انتشار 2006